Introduces a new, simplified classification for stereoselective reactions based on changes in the number of chiral centres taking place, emphasizing the three-dimensional representations of transition states in which stereoselectivity is determined. Using stereochemical vocabulary in accordance with IUPAC rules, it covers analysis of factors in which asymmetric induction occurs, the interplay between steric and electronic effects, the importance of conformational control, advantages of intramolecularly and the majority of important reaction types used in modern stereoselective synthesis.

The Inside Flap Stereoselective Synthesis considers the methods available for the synthesis of simple target molecules, the majority containing not more than two chiral centres, as single stereoisomers. This volume focuses on the factors which give rise to the stereoselectivity and classifies stereoselective reactions accordingly. This classification, and the extensive use of 3-D representations, enables the student to understand the stereochemistry of these reactions and hence apply them to the synthesis of previously unseen target molecules as single stereoisomers.

About the Author

Robert S. Atkinson is the author of Stereoselective Synthesis, published by Wiley.

Publisher ‏ : ‎ Wiley; 1st edition (28 July 1995)

Language ‏ : ‎ English

Paperback ‏ : ‎ 542 pages

ISBN-10 ‏ : ‎ 0471954195

ISBN-13 ‏ : ‎ 9780471954194